A combination of various heart as well as great blood vessels abnormalities cause Hypoplastic left heart syndrome.

This syndrome presents at the time of birth which indicates these defects in the heart take place because of unusual slow development of some sections in the fetal heart. The situation occurs in the first eight weeks of pregnancy.

Children with HLHS have underdeveloped and small most of left side heart structures and this underdevelopment is different in different children. Mitral valve, left ventricle, aortic valve and aorta are some structures that usually affected by the condition.

However, underdeveloped and small left ventricle is considered the most serious defect in this condition.

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